1354567-82-0
英文名稱
Zotiraciclib diHCl (TG-02, SB-1317)
CAS
1354567-82-0
分子式
C23H25ClN4O
分子量
408.93
MOL 文件
1354567-82-0.mol
1354567-82-0 結構式
應用領域
用途一
Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.