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1353254-53-1

英文名稱 KRH 102053
CAS 1353254-53-1
分子式 C25H34N2O5S
分子量 474.61
MOL 文件 1353254-53-1.mol
1353254-53-1 結(jié)構(gòu)式 1353254-53-1 結(jié)構(gòu)式

基本信息

英文別名
KRH 102053
YRALDHSTDKVSML-UHFFFAOYSA-N

應(yīng)用領(lǐng)域

用途一
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.
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