135304-07-3
135304-07-3 結(jié)構(gòu)式
基本信息
中文別名
乙酰法尼基半胱氨酸N-乙?；?L-法呢基半胱氨酸
N-乙?；?S-法呢基-L-半胱氨酸
N-乙?；?S-TRANS,TRANS-法尼基-L-半胱氨酸
英文別名
AFCAFC USP/EP/BP
AC-CYS(FARNESYL)-OH
Ac-L-Cys(Farnesyl)-OH
AC-CYSTEINE(FARNESYL)-OH
N-Acetyl-L-farnesylcysteine
n-acetyl-s-farnesylcysteine
ACETYL-S-FARNESYL-L-CYSTEINE
N-ACETYL-S-FARNESYL-L-CYSTEINE
N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
所屬類別
生物化工：半胱氨酸類衍生物物理化學(xué)性質(zhì)
沸點(diǎn)566.1±50.0 °C(Predicted)
密度1.038±0.06 g/cm3(Predicted)
儲(chǔ)存條件-15°C
溶解度可溶于 DMSO（高達(dá) 25 mg/ml）或乙醇（高達(dá) 25 mg/ml）
酸度系數(shù)(pKa)3.31±0.10(Predicted)
形態(tài)淡黃色油狀物。
顏色深黃色
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP5.860 (est)
常見問題列表
生物活性
Arazine (N-Acetyl-S-farnesyl-L-cysteine) 是 G 蛋白和 G 蛋白偶聯(lián)受體 (G protein and G-protein coupled receptor) 信號(hào)傳導(dǎo)的細(xì)胞滲透性調(diào)節(jié)劑。Arazine 可與異戊烯化的 G 蛋白或其受體位點(diǎn)競爭，成為異戊二烯基半胱氨酸甲基轉(zhuǎn)移酶的底物。體外研究
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell.
體內(nèi)研究
Arazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED 50 ) of 55±12?μg/20?μl.
| Animal Model: | TPA-induced ear acute inflammation in mouse |
| Dosage: | 2000?μg/20?μl |
| Administration: | 2000?μg/20?μl; Applied on ear |
| Result: | Inhibited ear edema, as measured by ear weight. |