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1352280-98-8

中文名稱 化合物 T26981
英文名稱 Formic acid, compd. with 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine (1:)
CAS 1352280-98-8
分子式 C21H26N6O4S
分子量 458.54
MOL 文件 1352280-98-8.mol
1352280-98-8 結(jié)構(gòu)式 1352280-98-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T26981
英文別名
Ceralasertib formate
Formic acid, compd. with 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine (1:)

應(yīng)用領(lǐng)域

用途一
Ceralasertib, also known as AZD6738, is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.
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