1351169-31-7
中文名稱
PROTAC AR Degrader-4
英文名稱
PROTAC AR Degrader-4
CAS
1351169-31-7
常見問題列表
生物活性
PROTAC AR Degrader-4 包含 cIAP1 配體結(jié)合基團(tuán)，linker 和雄激素受體 (AR) 配體結(jié)合基團(tuán)?；?cIAP1 的降解劑也被稱為 SNIPER。靶點(diǎn)
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cIAP1
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體外研究
Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure.
Targeting proteins for degradation involves three steps.
1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein.
2, the target protein is polyubiquitinated by IAPs.
3, the polyubiquitinated protein is degraded by proteasome.