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13492-01-8

中文名稱 反苯環(huán)丙胺半硫酸鹽
英文名稱 Tranylcypromine Hemisulfate
CAS 13492-01-8
分子式 C18H24N2O4S
分子量 364.46
MOL 文件 13492-01-8.mol
更新日期 2024/12/24 08:41:06
13492-01-8 結(jié)構(gòu)式 13492-01-8 結(jié)構(gòu)式

基本信息

中文別名
反苯環(huán)丙胺半硫酸鹽
硫酸反苯環(huán)丙胺 標(biāo)準(zhǔn)品
反-2-苯基環(huán)丙基胺半硫酸鹽
反式-2-苯基環(huán)丙胺 半硫酸鹽
TRANYLCYPROMINE硫酸鹽
英文別名
parnate
tranylcyprominesulfate
tranylcyprominesulphate
phenylcycloprominesulfate
TRANYLCYPROMINE HEMISULFATE
Tranylcypromine Sulfate (125 mg)
TRANYLCYPROMINE HEMISULFATE SALT
Tranylcypromine Sulfate (1672905)
1-amino-2-phenylcyclopropanesulfate
trans,d,l-2-phenylcyclopropylaminesulfate
所屬類別
分析化學(xué):藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

儲存條件2-8°C
溶解度易溶于水;極微溶于乙醇(96%)和乙醚。
形態(tài)白色固體。
顏色白色
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。蒸餾水溶液可在 -20° 下保存長達(dá) 3 個月。
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安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險
危險性描述H300-H311+H331
危險品標(biāo)志T
危險類別碼23/24/25
安全說明36/37/39-45
危險品運(yùn)輸編號UN 2811 6.1/PG 2
WGK Germany3
RTECS號GZ2625000
危險等級6.1(b)
包裝類別III
海關(guān)編碼2921490002

常見問題列表

生物活性
Tranylcypromine (Parnate)是不可逆型單胺氧化酶 (MAO)抑制劑。
體外研究

Tranylcypromine (10 nM to 10 μM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity.

體內(nèi)研究

Tranylcypromine treatment significantly and substantially reduces the lesion size and improves generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, tranylcypromine treatment results in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT and lesion growth. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 μg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry. Tranylcypromine causes the greatest increase in cell proliferation in the cerebellum.

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