134865-70-6
134865-70-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10198 英文別名
AH 0028-M-PDOT
8 M PDOT,8MPDOT
8-METHOXY-2-PROPIONAMIDOTETRALIN
Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
物理化學(xué)性質(zhì)
沸點(diǎn)447.8±45.0 °C(Predicted)
密度1.09±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度Soluble to 50 mM in ethanol and to 100 mM in DMSO
酸度系數(shù)(pKa)15.87±0.20(Predicted)
形態(tài)Powder
顏色White to off-white
常見問題列表
生物活性
8-M-PDOT (AH-002) 是一種選擇性的褪黑激素 MT2 受體激動(dòng)劑。8-M-PDOT 對(duì) MT2 的選擇性是 MT1 受體的 5.2 倍。8-M-PDOT 結(jié)合人類重組 MT1 和 MT2 受體，其 pKi 值分別為 8.23 和 8.95。8-M-PDOT 具有抗焦慮活性。靶點(diǎn)
pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)
體內(nèi)研究
8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect.
| Animal Model: | Male Wistar rats (280-320 g) with Rotenone |
| Dosage: | 10 μg/μL |
| Administration: | Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes |
| Result: | Increased percentage of time spent in the open arms and in the number of open arms entries. |