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134649-29-9

中文名稱 β-Amyloid (12-20)
英文名稱 β-Amyloid (12-20)
CAS 134649-29-9
分子式 C57H83N15O11
分子量 1154.36
MOL 文件 134649-29-9.mol
134649-29-9 結(jié)構(gòu)式 134649-29-9 結(jié)構(gòu)式

基本信息

中文別名
Β淀粉樣肽(12-20)
英文別名
Β-AMYLOID 12-20
β-Amyloid (12-20)
VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE
L-Phenylalanine, L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-

物理化學(xué)性質(zhì)

沸點1589.3±65.0 °C(Predicted)
密度1.264±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.50±0.10(Predicted)
形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
β-Amyloid (12-20) 是 β-Amyloid 的多肽片段。
體外研究

β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was aged 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

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