134029-62-2
中文名稱
3,4,5,4'-四甲氧基二苯乙烯
英文名稱
3,4,5,4'-TETRAMETHOXYSTILBENE
CAS
134029-62-2
分子式
C18H20O4
分子量
300.35
MOL 文件
134029-62-2.mol
更新日期
2024/12/16 10:21:14
134029-62-2 結(jié)構(gòu)式
基本信息
中文別名
3,4,5,4'-四甲氧基二苯乙烯 英文別名
DMU 212DMU-212
DMU 212
DMU212
3,4,5,4'-TETRAMETHOXYSTILBENE
(E)-3,4,5,4′-Tetramethoxystilbene
(E)-3,4,5,4'-Tetramethoxystilbene >=98% (HPLC)
(E)-1,2,3-Trimethoxy-5-[2-(4-methoxyphenyl)ethenyl]benzene
1,2,3-Trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
Benzene, 1,2,3-trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-
物理化學(xué)性質(zhì)
熔點157-159℃
沸點444.0±40.0 °C(Predicted)
密度1.117
儲存條件2-8°C
溶解度DMSO：可溶5mg/mL，澄清（加熱）
形態(tài)粉末
顏色白色至米色
常見問題列表
生物活性
DMU-212 是一種白藜蘆醇 (HY-16561) 甲基化衍生物，具有抗分裂、抗增殖、抗氧化和促進(jìn)細(xì)胞凋亡的活性。DMU-212 通過誘導(dǎo)凋亡 (apoptosis) 和激活 ERK1/2 蛋白導(dǎo)致有絲分裂停止。DMU-212 具有口服活性。體外研究
DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 cells human melanoma cells.
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces G2/M arrest and apoptosis in cancer cells.
DMU-212 induces mitotic arrest, apoptosis and activation of ERK1/2 protein.
Cell Proliferation Assay
| Cell Line: | A375 cells, MeWo cells, M5 cells, Bro cells |
| Concentration: | 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM |
| Incubation Time: | 96 hours |
| Result: | Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC 50 =0.5 μM for A375 and Bro and IC 50 = 1.25 μM for MeWo and M5 cells). |
Cell Cycle Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. |
Western Blot Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased. |
體內(nèi)研究
DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer.
| Animal Model: | 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage, three times a week, for 14 days |
| Result: | Lower tumor burden. |