1332708-14-1
中文名稱
CS-2357
英文名稱
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
CAS
1332708-14-1
分子式
C26H38N6O2
分子量
466.62
MOL 文件
1332708-14-1.mol
更新日期
2024/12/10 17:13:38
1332708-14-1 結(jié)構(gòu)式
基本信息
中文別名
化合物PF4840154 英文別名
CS-2357N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide
4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
物理化學(xué)性質(zhì)
密度1.164±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
酸度系數(shù)(pKa)13.71±0.46(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
PF-4840154 是有效，選擇性的大鼠和人 TrpA1 通道激動(dòng)劑，EC50 分別為 97 和 23 nM。PF-4840154 誘導(dǎo) TrpA1 介導(dǎo)的小鼠傷害行為。靶點(diǎn)
IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)
體內(nèi)研究
PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.
| Animal Model: | Female CD1 mice (25-30g) (In TrpA1+/+ mice) |
| Dosage: | 30 nmol |
| Administration: | Intraplantar (i.pl) injection |
| Result: | Elicited robust licking behavior. |