13312-52-2
13312-52-2 結(jié)構(gòu)式
基本信息
中文別名
(9Z)-Β-胡蘿卜素 英文別名
(9Z)-β-CaroteneNeo-β-carotene U
neo U-β-Carotene
9-cis-β-Carotene
(9Z)-β,β-Carotene
(9Z)-beta-Carotene
物理化學(xué)性質(zhì)
沸點654.7±22.0 °C(Predicted)
密度0.941±0.06 g/cm3(Predicted)
儲存條件-20°C
形態(tài)Solid
顏色Light brown to brown
BRN3227021
常見問題列表
生物活性
9-cis-β-Carotene 一種視網(wǎng)膜的前體 (precursor)，由 β-胡蘿卜素加氧酶 1 (BCMO1) 裂解產(chǎn)生 9-cis-retinal。9-cis-β-Carotene 在動物模型中抑制視網(wǎng)膜光感受器變性和幫助恢復(fù)視網(wǎng)膜功能。9-cis-β-Carotene 有潛力用于先天性靜止夜盲癥的研究。體外研究
9-cis-β-Carotene (1 μM; 18 hours) formulates with the Miglyol 810 and the“antioxidant mix” is incubated to eye cups. The eye cups are isolated from the neuro-retina attached to the underlying RPE tissue from?RPE65rd12 mouse. It prevents S- and M-cones degeneration and leads to over 2- and 9- fold higher m-opsin and s-opsin positive staining compares to the control group.
體內(nèi)研究
In a mouse model of retinoid cycle defect, RPE65rd12. Mice with an extract of Dunaliella Bardawil algae rich in 9-cis-β-Carotene (9CBC) rescues retinal function and preserves cone structure by oral administration.