132819-92-2
中文名稱
1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
英文名稱
1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester
CAS
132819-92-2
分子式
C18H17NO4S
分子量
343.4
MOL 文件
132819-92-2.mol
更新日期
2023/03/20 15:41:27
132819-92-2 結(jié)構(gòu)式
基本信息
中文別名
化合物NOD-IN-11-甲苯磺酰-1H-吲哚-2-甲酸乙酯
英文別名
NOD-IN-1MDK19922
NOD inhibitor 1
ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate
NOD-IN-1
COMPOUND 4
MDK19922
MDK 19922
MDK-19922.
NODIN1,inhibit,NOD IN 1,Inhibitor,NOD-like Receptor (NLR)
1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester
1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester
物理化學(xué)性質(zhì)
熔點98-99 °C
沸點523.3±52.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
形態(tài)A crystalline solid
顏色White to off-white
1-甲苯磺酰-1H-吲哚-2-甲酸乙酯價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100691 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 NOD-IN-1 | 132819-92-2 | 1mg | 800元 |
| 2024/11/08 | HY-100691 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 NOD-IN-1 | 132819-92-2 | 10mM * 1mLin DMSO | 1130元 |
| 2024/11/08 | S0004 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 NOD-IN-1 | 132819-92-2 | 5mg | 1850.91元 |
常見問題列表
生物活性
NOD-IN-1 (MDK19922, Compound 4) 是一種有效的 nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) 和 NOD2 的混合抑制劑，對應(yīng)的IC50值分別為5.74 μM和6.45 μM。靶點
IC50: 5.74 μM (NOD1), 6.45 μM (NOD2)
體外研究
NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC 50 (NOD1)=5.74 μM; IC 50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.