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132173-07-0

中文名稱 SR 31747
英文名稱 SR 31747
CAS 132173-07-0
MOL 文件 132173-07-0.mol
132173-07-0 結(jié)構(gòu)式 132173-07-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16926
英文別名
SR 31747
HKHPCMBPASXYGP-KVVVOXFISA-N
(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine
3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine
(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride
3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride
(Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE

物理化學(xué)性質(zhì)

形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
SR-31747 是一種具有免疫抑制和抗炎特性的 sigma 配體。SR-31747 通過抑制固醇異構(gòu)酶來(lái)阻止細(xì)胞增殖。
靶點(diǎn)

Sigma ligand

體外研究

SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner.

體內(nèi)研究

In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED 50 , 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.

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