132-60-5
132-60-5 結構式
基本信息
阿托方
喹苯甲酸
苯基金雞寧酸
2-苯辛可寧酸
2-苯辛可寧酸
2-苯-4-喹啉甲酸
2-苯基-4-喹啉羧酸
2-苯基喹啉-4-羧酸
2-苯基-4-喹啉甲酸
agotan
alutyl
atigoa
atocin
atofan
tophol
vantyl
RHEUMIN
artamin
物理化學性質
安全數(shù)據(jù)
常見問題列表
辛可芬的合成路線很多，將苯甲醛、苯胺和丙酮酸各一分子在乙醇溶液中加熱，可一鍋法制備得到。或以取代吲哚醌和取代苯乙酮為原料,無水乙醇為溶劑,在氫氧化鉀的存在下加熱反應生成取代2-苯基-4-喹啉羧酸。2-苯基-4-喹啉羧酸的合成反應式如下圖：
Cinchophen（2 - 苯基喹啉-4 - 羧酸）是一個功能強大的抗菌劑。 獸醫(yī)將Cinchophen和潑尼松龍組合使用，治療動物的關節(jié)炎。由于發(fā)現(xiàn)cinchophen會引起嚴重的肝損傷， 1930s停止了該藥在人體的使用。
Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (V d area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t 1/2β ) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs. Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (C max ) of 77.75 μg/ml and the time of Cmax (t max ) is 2.76 hours. The plasma concentration time curve (AUC 0-∞ ) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.