13095-48-2
中文名稱
S-2-羥基戊二酸
英文名稱
(2S)-2-hydroxypentanedioic acid
CAS
13095-48-2
分子式
C5H8O5
分子量
148.11
MOL 文件
13095-48-2.mol
13095-48-2 結(jié)構(gòu)式
基本信息
中文別名
L-2-羥基戊二酸 英文別名
L-2-HydroxyglutarateL--Hydroxyglutaric Acid
L-α-Hydroxyglutaric Acid
L-2-Hydroxyglutaric acid
(S)-2-Hydroxyglutaric acid
(2S)-2-Hydroxyglutaric Acid
L-alpha-Hydroxyglutaric acid
(S)-alpha-Hydroxyglutaric acid
(2S)-2-hydroxypentanedioic acid
Pentanedioic acid,2-hydroxy-, (2S)-
物理化學(xué)性質(zhì)
沸點(diǎn)394.2±27.0 °C(Predicted)
密度1.508±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
酸度系數(shù)(pKa)3.67±0.10(Predicted)
形態(tài)Liquid
顏色Colorless to light yellow
常見問題列表
生物活性
L-2-Hydroxyglutaric acid ((S)-2-Hydroxyglutaric acid) 是一種表觀遺傳修飾因子,可用于腎癌研究。L-2-Hydroxyglutaric acid 可抑制組蛋白去甲基化酶 (histone demethylases),從而促進(jìn)組蛋白甲基化。靶點(diǎn)
Human Endogenous Metabolite
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體外研究
L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes.