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130849-58-0

中文名稱 130849-58-0
英文名稱 Z-321
CAS 130849-58-0
分子式 C19H24N2O2S
分子量 344.47
MOL 文件 130849-58-0.mol
130849-58-0 結(jié)構(gòu)式 130849-58-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T17279
英文別名
Z-321
Thiazolidine, 3-[(2,3-dihydro-1H-inden-2-yl)acetyl]-4-(1-pyrrolidinylcarbonyl)-, (4R)- (9CI)

物理化學(xué)性質(zhì)

沸點588.8±50.0 °C(Predicted)
密度1.265±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 250 mg/mL (725.75 mM)
酸度系數(shù)(pKa)-0.84±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
130849-58-0價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-19123130849-58-0
Z-321
130849-58-01mg2600元
2024/11/08HY-19123130849-58-0
Z-321
130849-58-05mg6000元
2024/08/19HY-19123130849-58-0
Z-321
130849-58-010mg7200元

常見問題列表

生物活性
Z-321 是一個脯氨酰內(nèi)肽酶 (PEP) 抑制劑。
靶點

PEP

體內(nèi)研究

Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity.

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