1303993-73-8
中文名稱
CHPG SODIUM SALT
英文名稱
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
CAS
1303993-73-8
分子式
C8H7ClNNaO3
分子量
223.589
MOL 文件
1303993-73-8.mol
更新日期
2023/03/20 15:41:25
1303993-73-8 結(jié)構(gòu)式
CHPG SODIUM SALT價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-101364A | CHPG SODIUM SALT CHPG sodium salt | 1303993-73-8 | 5mg | 500元 |
| 2024/11/08 | HY-101364A | CHPG SODIUM SALT CHPG sodium salt | 1303993-73-8 | 10 mg | 800元 |
| 2024/11/08 | HY-101364A | CHPG SODIUM SALT CHPG sodium salt | 1303993-73-8 | 25 mg | 1750元 |
常見問題列表
生物活性
CHPG sodium salt 是一個選擇性的 mGluR5 激動劑，并且通過 TSG-6/NF-κB 途徑減弱 BV2 小神經(jīng)膠質(zhì)細胞 SO2 誘導的氧化應激和炎癥。 CHPG sodium salt 通過 ERK 和 Akt 途徑在體外和體內(nèi)預防創(chuàng)傷性腦損傷 (TBI)。靶點
|
mGlu 5
|
NF-κB
|
ERK
|
Akt
|
體外研究
CHPG sodium salt (10-500?μM; 24?hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG sodium salt (0.5?mM; 30?mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG sodium salt (0.5 mM; 30?mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
| Cell Line: | BV2 microglial cells |
| Concentration: | 10, 50, 100 and 500?μM |
| Incubation Time: | 24?hours |
| Result: | Increased the cell viability. |
Apoptosis Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5?mM |
| Incubation Time: | 30?mins |
| Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5?mM |
| Incubation Time: | 30?mins |
| Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
體內(nèi)研究
CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
| Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
| Dosage: | 250 nM |
| Administration: | Injection; for 7 days |
| Result: | Reduced significantly cerebral lesion volume. |