130112-42-4
中文名稱
MIVOTILATE
英文名稱
Unii-0789652qul
CAS
130112-42-4
分子式
C12H14N2O3S3
分子量
330.45
MOL 文件
130112-42-4.mol
更新日期
2023/03/20 15:41:25
130112-42-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16082 英文別名
Ccris 8109Mivotilate
Unii-0789652qul
Mivotilate [inn]
YH439 >=98% (HPLC)
Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate
Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate
2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester
Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester
物理化學(xué)性質(zhì)
密度1.467±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度二甲基亞砜：≥5mg/mL
酸度系數(shù)(pKa)4.89±0.70(Predicted)
形態(tài)固體
顏色Light yellow to yellow
MIVOTILATE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 1mg | 1363元 |
| 2024/11/08 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 5mg | 3000元 |
| 2024/11/08 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 10 mM * 1 mLin DMSO | 3300元 |
常見問題列表
生物活性
Mivotilate 是一種非毒性的，有效的芳烴受體 (aryl hydrocarbon receptor) 激動(dòng)劑，具有護(hù)肝作用。靶點(diǎn)
Aryl hydrocarbon receptor
體外研究
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor.
體內(nèi)研究
Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats.