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130-01-8

中文名稱 千里光寧
英文名稱 SENECIONINE
CAS 130-01-8
分子式 C18H25NO5
分子量 335.39
MOL 文件 130-01-8.mol
更新日期 2024/12/16 10:53:11
130-01-8 結(jié)構(gòu)式 130-01-8 結(jié)構(gòu)式

基本信息

中文別名
千里光寧
千里光寧堿
千里光寧鹼
千里光堿/ 千里光寧
英文別名
qlgn
Aureine
SENECIONIN
Sencionine
SENECIONINE
Senecionine/Aureine
16-dione,12-hydroxy-senecionan-1
12-Hydroxysenecionan-11,16-dione
Senecionan-11,16-dione, 12-hydroxy-
(15cis)-12-Hydroxysenecionan-11,16-dione
所屬類別
天然產(chǎn)物:生物堿

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于菊三七,千里光Senecio scandens Buch.-Ham. ex D. Don,歐洲千里光 Senecio vulgaris L.全草 菊葉千里光 S.chrysanthemoides DC.根 牙克貝千里光 S.jacobaea L.。
熔點(diǎn)236 °C(lit.)
比旋光度D25 -55.1° (c = 0.034 in chloroform)
沸點(diǎn)472.03°C (rough estimate)
密度1.266 g/cm3
折射率1.5100 (estimate)
儲(chǔ)存條件−20°C
溶解度DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml
酸度系數(shù)(pKa)12.81±0.40(Predicted)
形態(tài)neat
顏色White to off-white
旋光性 (optical activity)[α]25/D 55.1°, c = 0.034% in chloroform
BRN8162955
InChIKeyHKODIGSRFALUTA-JTLQZVBZSA-N
LogP0.880 (est)
EPA化學(xué)物質(zhì)信息Senecionine (130-01-8)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H300+H310+H330
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼25
安全說明45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 3
WGK Germany3
RTECS號(hào)VT5710000
危險(xiǎn)等級(jí)6.1(a)
包裝類別II
毒害物質(zhì)數(shù)據(jù)130-01-8(Hazardous Substances Data)
毒性LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris)

應(yīng)用領(lǐng)域

用途1
用于含量測定/鑒定/藥理實(shí)驗(yàn)等。
用途2
千里光寧具有凝血止血、消炎和抗病毒的作用。
千里光寧價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-N2560千里光寧
Senecionine
130-01-81mg525元
2024/11/08HY-N2560千里光寧
Senecionine
130-01-85mg1295元
2024/11/08HY-N2560千里光寧
Senecionine
130-01-810mg2100元

常見問題列表

生物活性
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) 是一種從 Senecio vulgaris 中分離出來的吡咯里西啶生物堿。 Senecionine對(duì)動(dòng)物和人類有毒。
體外研究

Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.

體內(nèi)研究

Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.

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