129693-13-6
129693-13-6 結(jié)構(gòu)式
常見問題列表
生物活性
Sp-8-CPT-cAMPS，一種 cAMP 類似物，是 cAMP 依賴性蛋白激酶 A PKA I 和 PKA II 的有效和選擇性的激活劑。Sp-8-CPT-cAMPS 優(yōu)先選擇 RI 的位點(diǎn) A 與 RII 的位點(diǎn) B。靶點(diǎn)
PKA
體外研究
Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells.
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells.
Sp-8-CPT-cAMPS (10?μM; 30?min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis.