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1254979-66-2

中文名稱 1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-
英文名稱 1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-
CAS 1254979-66-2
分子式 C22H22F5N5
分子量 451.44
MOL 文件 1254979-66-2.mol
1254979-66-2 結(jié)構(gòu)式 1254979-66-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T27686
英文別名
JNJ46356479
JNJ-46356479
JNJ 46356479
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)-

應(yīng)用領(lǐng)域

用途一
JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256. JNJ-46356479 is in vivo active, sw-EEG at 3mg/kg, p.o. JNJ-46356479 represents a more balanced profile that offers a significant improvement on the druglike attributes compared to previously reported leads.
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