天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>1253186-56-9

1253186-56-9

中文名稱 1253186-56-9
英文名稱 GSK-7975A
CAS 1253186-56-9
分子式 C18H12F5N3O2
分子量 397.3
MOL 文件 1253186-56-9.mol
更新日期 2024/12/13 09:53:01
1253186-56-9 結(jié)構(gòu)式 1253186-56-9 結(jié)構(gòu)式

基本信息

中文別名
化合物GSK-7975A
2,6-二氟-N-[1-[[4-羥基-2-(三氟甲基)苯基]甲基]-1H-吡唑-3-基]苯甲酰胺
英文別名
GSK-7975A
2,6-Difluoro-N-(1-{[4-hydroxy-2-(trifluoromethyl)phenyl]methyl} 1H-pyrazol-3-yl)benzamide
Benzamide, 2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-3-yl]-

物理化學性質(zhì)

沸點462.2±45.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
溶解度DMSO:90.0(Max Conc. mg/mL);226.53(Max Conc. mM)
酸度系數(shù)(pKa)8.82±0.20(Predicted)
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335

常見問題列表

生物活性
GSK-7975A是高效有口服活性的 CRAC 通道抑制劑。
體外研究

GSK-7975A reduces FcεRI-dependent Ca 2+ influx and 3 μM GSK-7975A reduces the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα) by up to 50%. GSK-7975A inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety species. GSK-7975A completely inhibits calcium influx through CRAC channels. This leads to inhibition of the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations. Mast cells from guinea-pig and mouse preparations are not inhibited by GSK-7975A; however cytokine release is fully blocked from T-cells in a mouse preparation. GSK-7975A inhibits toxin-induced activation of ORAI1 and/or activation of Ca 2+ currents after Ca 2+ release, in a concentration-dependent manner, in mouse and human pancreatic acinar cells (inhibition >90% of the levels observed in control cells). GSK-7975A also prevents activation of the necrotic cell death pathway in mouse and human pancreatic acinar cells.

體內(nèi)研究

GSK-7975A inhibits local and systemic features of acute pancreatitis in TLCS-AP, CER-AP, FAEE-AP, in dose- and time-dependent manners. GSK-7975A significantly reduces increases in serum amylase, IL6, and pancreatic MPO levels; lung MPO is reduced significantly by low dose only. GSK-7975A markedly reduces pancreatic histopathology in TLCS-AP, CER-AP, and FAEE-AP.

"1253186-56-9" 相關產(chǎn)品信息