125314-13-8
中文名稱(chēng)
GSK-3Β抑制劑(CP21R7)
英文名稱(chēng)
CP21R7(CP21)
CAS
125314-13-8
分子式
C19H15N3O2
分子量
317.34
MOL 文件
125314-13-8.mol
更新日期
2024/12/23 17:39:04
125314-13-8 結(jié)構(gòu)式
基本信息
中文別名
化合物CP21R7GSK-3Β抑制劑(CP21R7)
3-(3-氨基苯基)-4-(1-甲基-1H-吲哚-3-基)吡咯-2,5-二酮
英文別名
CP21R7CS-2352
CP21R7(CP21)
CP21 (CP21R7)
3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione
3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione
3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)627.4±55.0 °C(Predicted)
密度1.37±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度insoluble in EtOH; insoluble in H2O; ≥14.25 mg/mL in DMSO
酸度系數(shù)(pKa)7.79±0.60(Predicted)
形態(tài)結(jié)晶固體
顏色Yellow to orange
GSK-3Β抑制劑(CP21R7)價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100207 | GSK-3Β抑制劑(CP21R7) CP21R7 | 125314-13-8 | 10mM * 1mLin DMSO | 768元 |
| 2024/11/08 | HY-100207 | GSK-3Β抑制劑(CP21R7) CP21R7 | 125314-13-8 | 5mg | 1100元 |
| 2024/11/08 | HY-100207 | GSK-3Β抑制劑(CP21R7) CP21R7 | 125314-13-8 | 10mg | 1600元 |
常見(jiàn)問(wèn)題列表
生物活性
CP21R7 (CP21) 是一種有效的、選擇性的GSK-3β抑制劑，能有效激活經(jīng)典Wnt信號(hào)通路。靶點(diǎn)
| Target | Value |
|
GSK-3β
(Cell-free assay) |
體外研究
CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC 50 of 1.8 nM; the IC 50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.