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1232841-78-9

英文名稱 PBT434
CAS 1232841-78-9
分子式 C12H14BrCl2N3O2
分子量 383.07
MOL 文件 1232841-78-9.mol
1232841-78-9 結(jié)構(gòu)式 1232841-78-9 結(jié)構(gòu)式

基本信息

英文別名
PBT434

應(yīng)用領(lǐng)域

用途一
PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.
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