1227301-51-0
基本信息
PHILANTHOTOXIN 74二鹽酸鹽
化合物PHILANTHOTOXIN 74 鹽酸鹽
PhTx-74 dihydrochloride
Philanthotoxin 74 dihydrochloride
Philanthotoxin 74 (hydrochloride)
Benzenepropanamide, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]-, hydrochloride (1:2), (αS)-
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-104020A | 1227301-51-0 Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 1mg | 500元 |
2024/11/08 | HY-104020A | 1227301-51-0 Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 5mg | 800元 |
2024/11/08 | HY-104020A | 1227301-51-0 Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 10mM * 1mLin DMSO | 893元 |
常見(jiàn)問(wèn)題列表
IC50: 296 nM (GluR1), 296 nM (GluR1)
Ki: 0.29 μM (GluR5Q)
Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC 50 values of about 30 μM, in both the presence and absence of γ-2.