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1227301-51-0

中文名稱 1227301-51-0
英文名稱 Philanthotoxin 74
CAS 1227301-51-0
分子式 C24H42N4O3.2HCl
更新日期 2024/12/16 10:25:30
分子量 471.08
MOL 文件 1227301-51-0.mol
1227301-51-0 結(jié)構(gòu)式 1227301-51-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16524
PHILANTHOTOXIN 74二鹽酸鹽
化合物PHILANTHOTOXIN 74 鹽酸鹽
英文別名
PhTx 74。2HCl
PhTx-74 dihydrochloride
Philanthotoxin 74 dihydrochloride
Philanthotoxin 74 (hydrochloride)
Benzenepropanamide, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]-, hydrochloride (1:2), (αS)-
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,Room Temperature
溶解度DMSO : 100 mg/mL (197.03 mM; Need ultrasonic)H2O : 50 mg/mL (98.51 mM; Need ultrasonic)
形態(tài)粉末
顏色White to light yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
1227301-51-0價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-104020A1227301-51-0
Philanthotoxin 74 dihydrochloride
1227301-51-01mg500元
2024/11/08HY-104020A1227301-51-0
Philanthotoxin 74 dihydrochloride
1227301-51-05mg800元
2024/11/08HY-104020A1227301-51-0
Philanthotoxin 74 dihydrochloride
1227301-51-010mM * 1mLin DMSO893元

常見(jiàn)問(wèn)題列表

生物活性
Philanthotoxin 74 dihydrochloride (PhTx 74) 是 AMPAR 的拮抗劑; 抑制 GluR3 和 GluR1 的 IC50 值分別為263和296 nM。
靶點(diǎn)

IC50: 296 nM (GluR1), 296 nM (GluR1)

Ki: 0.29 μM (GluR5Q)

體外研究

Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC 50 values of about 30 μM, in both the presence and absence of γ-2.

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