1218816-71-7
中文名稱(chēng)
1218816-71-7
英文名稱(chēng)
(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide
CAS
1218816-71-7
分子式
C22H30N4O3
分子量
398.5
MOL 文件
1218816-71-7.mol
1218816-71-7 結(jié)構(gòu)式
基本信息
中文別名
鞘氨醇激酶1(SPHK1)抑制劑(SK1-IN-1) 英文別名
SK1-IN-1SK1 inhibitor 1
(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide
2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)-
物理化學(xué)性質(zhì)
密度1.200±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)14.20±0.40(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
SK1-IN-1是一種有效的鞘氨醇激酶1 (SPHK1) 抑制劑，IC50 值為58 nM。靶點(diǎn)
IC50: 58 nM (SPHK1)
體內(nèi)研究
SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.