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121104-96-9

中文名稱 CELGOSIVIR
CAS 121104-96-9
分子式 C12H21NO5
分子量 259.3
MOL 文件 121104-96-9.mol
121104-96-9 結(jié)構(gòu)式 121104-96-9 結(jié)構(gòu)式

基本信息

英文別名
BuCast
MX3253
MBI 3253
MDL 28574
celgosivir
Celgosivir (free base)
6-O-butyl castanospermine
6-Butyryl castanospermine
Castanospermine 6-butyrate
MDL28574
MDL-28574
MDL 28574

物理化學(xué)性質(zhì)

熔點114-115 °C
沸點422.9±45.0 °C(Predicted)
密度1.33±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.14±0.70(Predicted)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335

常見問題列表

生物活性
Celgosivir (MBI 3253; MDL 28574; MX3253) 是 α-葡萄糖苷酶 I (α-glucosidase I) 抑制劑,在體外實驗中的 IC50 值為 1.27 μM。
靶點

IC50: 1.27 μM (α-glucosidase I)

體外研究

Celgosivir is more effective (IC 50 =20 μM) than the parent molecule (IC 50 =254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 with an IC 50 of 2.0±2.3 μM. Bovine viral diarrhoea virus (BVDV) is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC 50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively. Celgosivir inhibits DENV2 replication with an EC 50 of 0.2 μM. The EC 50 values against DENV1, 3 and 4 are less than 0.7 μM.

體內(nèi)研究

Celgosivir fully protects AG129 mice from lethal infection with a mouse adapted dengue virus at a dose of 50 mg/kg twice daily (BID) for 5 days and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25 or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice shows that it rapidly metabolizes to castanospermine. During primary infection with a mouse-adapted DENV strain S221, mice shows increased viremia on day 3, yet 80% survived day 10 with virus completely cleared by day 8.

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