1206170-62-8
中文名稱
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
英文名稱
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
CAS
1206170-62-8
分子式
C17H20N6O
分子量
324.38
MOL 文件
1206170-62-8.mol
1206170-62-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T17007 英文別名
TC Mps1 124-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
物理化學(xué)性質(zhì)
沸點(diǎn)601.0±55.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度<32.44mg/ml in DMSO; <6.49mg/ml in ethanol
酸度系數(shù)(pKa)16.23±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12 | 1206170-62-8 | 1mg | 1750元 |
| 2024/11/08 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12 | 1206170-62-8 | 5mg | 5200元 |
| 2024/08/19 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12 | 1206170-62-8 | 10mg | 8800元 |
常見問題列表
生物活性
TC-Mps1-12 是一種高效、選擇性的 Mps1 抑制劑，其 IC50 值為 6.4 nM。靶點(diǎn)
IC50: 6.4 nM (Mps1)
體外研究
TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay.
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC
50
values of 0.84 μM.
Cell Viability Assay
| Cell Line: | 549 cells |
| Concentration: | |
| Incubation Time: | 72 hours |
| Result: | Inhibited the growth of cells in a dose-dependent manner and with an IC 50 values of 0.84 μM. |
體內(nèi)研究
TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss.
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg.
| Animal Model: | A549 mouse xenograft model |
| Dosage: | 25 mg/kg, 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration; once daily; for 19 days |
| Result: | Inhibited the growth of A549 cells in a dose-dependent manner. |
| Animal Model: | A549 mouse xenograft model (pharmacokinetic ) |
| Dosage: | 25 mg/kg |
| Administration: | Oral administration |
| Result: | C max = 3542 ng/mL, AUC = 6604 ng h/mL |