120241-79-4
120241-79-4 結構式
基本信息
化合物3-TYP
3-(1H-1,2,3-三唑-4-基)吡啶
3-(1H-1,2,3-三唑-5-基)吡啶
CS-2754
Pyridine(3-TYP)
3-TYP
3 TYP
3TYP
3-triazol-4-yl) pyridine
3-(1H-1,2,3-triazol-4-yl)pyridine
Pyridine,3-(1H-1,2,3-triazol-5-yl)-
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)
3-(1H-1
2
3-TRIAZOL-4-YL) PYRIDINE
3 TYP
3TYP
物理化學性質
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-108331 | 吡啶-3-乙炔 3-TYP | 120241-79-4 | 5mg | 600元 |
| 2024/11/08 | HY-108331 | 吡啶-3-乙炔 3-TYP | 120241-79-4 | 10mM * 1mLin DMSO | 660元 |
| 2024/11/08 | S8628 | 吡啶-3-乙炔 3-TYP | 120241-79-4 | 5mg | 795.01元 |
常見問題列表
| Target | Value |
|
SIRT3
(cell-free) | 16 nM |
|
SIRT1
(cell-free) | 88 nM |
|
SIRT2
(cell-free) | 92 nM |
在暴露于鎘的HepG2細胞中，3-TYP可減弱由褪黑色素誘導的去乙?；疭OD2表達增加及抑制SOD2活性。
3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.