1196800-39-1
中文名稱
1196800-39-1
英文名稱
Omadacycline (hydrochloride)
CAS
1196800-39-1
分子式
C29H41ClN4O7
分子量
593.12
MOL 文件
1196800-39-1.mol
更新日期
2024/11/15 18:20:32
1196800-39-1 結構式
基本信息
英文別名
omadacycline HClPTK0796 hydrochloride
PTK-0796 hydrochloride
PTK 0796 hydrochloride
Amadacycline hydrochloride
Omadacycline (hydrochloride)
PTK 0796 HYDROCHLORIDE
PTK-0796 HYDROCHLORIDE
PTK0796 HYDROCHLORIDE
AMADACYCLINE HYDROCHLORIDE
(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
應用領域
用途一
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.