1191385-19-9
中文名稱
[N/A]
英文名稱
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
CAS
1191385-19-9
分子式
C26H21Cl3N8
分子量
551.87
MOL 文件
1191385-19-9.mol
更新日期
2024/12/24 19:29:54
1191385-19-9 結構式
基本信息
中文別名
B-RAF 抑制劑 1 二鹽酸鹽化合物B-RAF INHIBITOR 1 DIHYDROCHLORIDE
N5-(3-(9H-嘌呤-6-基)吡啶-2-基)-N1-(4-氯苯基)-6-甲基異喹啉-1,5-二胺二鹽酸鹽
英文別名
MFCD187826765-isoquinolinediamine
B-Raf inhibitor 1 2HCl
Raf inhibitor 1 dihydrochloride
B-Raf inhibitor 1 dihydrochloride
n1-(4-chlorophenyl)-6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-
N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridyl]isoquinoline-1,5-diamine dihydroc
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride
N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride
所屬類別
生物化工：激動劑抑制劑B-Raf 抑制劑 1 二鹽酸鹽價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | S6660 | [N/A] B-Raf inhibitor 1 (Compound 13) dihydrochloride | 1191385-19-9 | 5mg | 1285.95元 |
| 2024/11/08 | S6660 | [N/A] B-Raf inhibitor 1 (Compound 13) dihydrochloride | 1191385-19-9 | 25mg | 5627.35元 |
常見問題列表
生物活性
B-Raf inhibitor 1 (Compound 13)是一種IIA型Raf抑制劑，與DFG-out構象結合，對B-Raf(WT)，B-Raf(V600E)和C-Raf的ki分別為1 nM，1 nM和0.3 nM。靶點
| Target | Value |
|
C-Raf
(Cell-free assay) | 0.3 nM(Ki) |
|
B-Raf(WT)
(Cell-free assay) | 1 nM(Ki) |
|
B-Raf(V600E)
(Cell-free assay) | 1 nM(Ki) |
體外研究
B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.