1186195-60-7
中文名稱(chēng)
3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶鹽酸鹽
英文名稱(chēng)
MTEP
CAS
1186195-60-7
分子式
C11H9ClN2S
分子量
236.721
MOL 文件
1186195-60-7.mol
更新日期
2024/12/03 15:40:36
1186195-60-7 結(jié)構(gòu)式
基本信息
中文別名
鹽酸MTEP3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶鹽酸鹽
英文別名
MTEP HCl3-((2-Methyl-1
3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride
3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1)
3-((2-METHYL-1
3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE
MTEP
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
物理化學(xué)性質(zhì)
熔點(diǎn)154-156℃ (isopropanol )
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
形態(tài)結(jié)晶固體
顏色淡奶油
水溶解性H2O: 30mg/mL, clear
常見(jiàn)問(wèn)題列表
生物活性
MTEP hydrochloride 是非競(jìng)爭(zhēng)性的 mGlu5 拮抗劑，IC50 和 Ki 分別為 5 nM 和16 nM。MTEP hydrochloride 產(chǎn)生抗帕金森病樣作用。靶點(diǎn)
|
mGluR5 5 nM (IC 50 ) |
mGluR5 16 nM (Ki) |
體內(nèi)研究
MTEP hydrochloride (3-5 mg/2 ml/kg; i.p.) inhibits the catalepsy induced (0.5 mg/kg/2 ml; i.p.) by this neuroleptic.
| Animal Model: | Male Wistar rats (weighing 215-315 g) |
| Dosage: | 3 or 5 mg/2 ml/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited the catalepsy induced by this neuroleptic. |