1184-78-7
1184-78-7 結(jié)構(gòu)式
基本信息
三甲基胺氧化物
三甲胺N-氧化物
無水三甲基胺-N-氧化物
無水三甲基胺 N-氧化物
Triox
trimethyloxamine
TRIMETHYLAMINOXIDE
Trimethylamine oxide
TRIMETHYLAMINE N-OXIDE
trimethyl-oxido-ammonium
Trimethylamine N-oxide,98%
TriMethylaMine N-oxide 98%
Trimethylamine N-oxide,TMANO
物理化學(xué)性質(zhì)
制備方法
將100ml三甲胺水溶液與600ml過氧化氫溶液相混合，在室溫放置24h后，如果還有胺的氣味，就再加100～200ml的過氧化氫溶液，當(dāng)所有胺均被氧化后，在減壓下蒸發(fā)至干。殘余物用乙醇-乙醚混合物重結(jié)晶。得二水合氧化三甲胺，為長針狀晶體，產(chǎn)率95%。
在油浴中減壓至1.33～1.6kpa并加熱到120℃，慢慢地升溫至150℃，當(dāng)水分被驅(qū)除后，升溫至180℃～200℃，純的無水氧化三甲胺即升華在瓶子較冷的頸部。
另一種脫水法：將45.0g二水合氧化三甲胺溶于300ml熱DMF中，盛于圓底燒瓶中進(jìn)行蒸餾。先在常壓下加熱以蒸去溶劑，直到沸點(diǎn)達(dá)到152～153℃。然后用水泵減壓以除去殘留的溶劑。蒸餾的末了將油浴的溫度慢慢地升至120℃。剩下的無水氧化三甲胺重30g.
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | T1362 | 無水三甲基胺N-氧化物 Trimethylamine N-Oxide Anhydrous | 1184-78-7 | 1G | 290元 |
| 2024/11/08 | HY-116084 | 三甲胺N-氧化物 Trimethylamine N-oxide | 1184-78-7 | 100mg | 500元 |
| 2024/11/08 | HY-116084 | 三甲胺N-氧化物 Trimethylamine N-oxide | 1184-78-7 | 10mM * 1mLin DMSO | 550元 |
常見問題列表
ROS/NLRP3 inflammasome
TGF-β/smad2
The size and migration of fibroblasts are increased after Trimethylamine N-oxide (TMAO) treatment compared with non-treated fibroblasts in vitro. Trimethylamine N-oxide increases TGF-β receptor I expression, which promotes the phosphorylation of Smad2 and up-regulates the expression of α-SMA and collagen I. The ubiquitination of TGF-βRI is decreased in neonatal mouse fibroblasts after Trimethylamine N-oxide treatment. Trimethylamine N-oxide also inhibits the expression of smurf2.
Trimethylamine N-oxide is frequently found in the tissues of a variety of marine organisms that protects against the adverse effects of temperature, salinity, high urea and hydrostatic pressure.
Trimethylamine N-oxide (TMAO) contributes to cardiovascular diseases by promoting inflammatory responses. C57BL/6 mice are fed a normal diet, high-choline diet and/or 3-dimethyl-1-butanol (DMB) diet. The levels of Trimethylamine N-oxide and choline are increased in choline-fed mice. Left ventricular hypertrophy, pulmonary congestion, and diastolic dysfunction are markedly exacerbated in heart failure with preserved ejection fraction (HFpEF) mice fed high-choline diets compared with mice fed the control diet. Myocardial fibrosis and inflammation were markedly increased in HFpEF mice fed high-choline diets compared with animals fed the control diet.