117857-45-1
中文名稱
氯瑞唑
英文名稱
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride
CAS
117857-45-1
分子式
C10H6Cl3N3
分子量
274.53
MOL 文件
117857-45-1.mol
更新日期
2023/03/20 15:41:25
117857-45-1 結(jié)構(gòu)式
基本信息
中文別名
氯瑞唑 英文別名
R-72063Loreclezole
LoreclezoleHCl
1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole
1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
1H-1,2,4-Triazole, 1-[(1Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride
物理化學(xué)性質(zhì)
儲存條件Inert atmosphere,2-8°C
溶解度<1.37mg/ml in DMSO; <1.37mg/ml in ethanol
形態(tài)Solid
顏色White to off-white
氯瑞唑價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-105272 | 氯瑞唑 Loreclezole | 117857-45-1 | 1 mg | 266元 |
| 2025/02/08 | HY-105272 | 氯瑞唑 Loreclezole | 117857-45-1 | 5mg | 590元 |
| 2025/02/08 | HY-105272 | 氯瑞唑 Loreclezole | 117857-45-1 | 10mM * 1mLin DMSO | 803元 |
常見問題列表
生物活性
Loreclezole 是一種抗癲癇化合物，是選擇性的 GABAA 受體 的調(diào)節(jié)劑，是 β2 或 β3 亞單位包含受體的正向變構(gòu)調(diào)節(jié)劑。靶點(diǎn)
GABA A receptor.
體內(nèi)研究
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.
| Animal Model: | Adult male Lister Hooded rats. |
| Dosage: | 10, 25, 50 or 75 mg/kg. |
| Administration: | IP, 60 min before measurement of seizure threshold. |
| Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |