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1165923-54-5

中文名稱 2(1H)-Isoquinolinepropanoic acid,6-[5-[3-cyano-4-(1-Methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-5-Methyl-,sodiuM salt(1:1)
英文名稱 2(1H)-Isoquinolinepropanoic acid,6-[5-[3-cyano-4-(1-Methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-5-Methyl-,sodiuM salt(1:1)
CAS 1165923-54-5
分子式 C25H27N4NaO4
分子量 470.5
MOL 文件 1165923-54-5.mol
1165923-54-5 結構式 1165923-54-5 結構式

基本信息

中文別名
化合物 T32006
英文別名
GSK2262167
GSK-2262167
GSK 2262167
GSK-2262167 sodium
LCIDCFMLDWPFGR-UHFFFAOYSA-N
2(1H)-Isoquinolinepropanoic acid,6-[5-[3-cyano-4-(1-Methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-5-Methyl-,sodiuM salt(1:1)

應用領域

用途一
GSK-2262167 is a potent S1P3-sparing and orally active S1P1 agonist. CGSK-2262167 is as efficacious as fingolimod in a collagen-induced arthritis model and shows excellent pharmacokinetic properties preclinically. Importantly, the selectivity of GSK-2262167 against S1P3 is responsible for an absence of cardiovascular signal in telemetered rats, even at high dose levels.
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