1164500-72-4
1164500-72-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12074 英文別名
ML 1452-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
Benzoic acid, 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-
所屬類別
生物：拮抗劑ML 145價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-107536 | ML 145 ML 145 | 1164500-72-4 | 5mg | 1200元 |
| 2024/11/08 | HY-107536 | ML 145 ML 145 | 1164500-72-4 | 10mM * 1mLin DMSO | 1320元 |
| 2024/11/08 | HY-107536 | ML 145 ML 145 | 1164500-72-4 | 10mg | 2000元 |
常見問題列表
生物活性
ML 145 是選擇性，競爭性的人 GPR35/CXCR8 拮抗劑，IC50/EC50 為 20.1 nM。ML 145 對 GPR35 的選擇性比 GPR55 (IC50/EC50=21.7 μM) 高超 1000 倍。 ML 145 對嚙齒動(dòng)物直系同源物的 GPR35 均無明顯活性。靶點(diǎn)
IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55)
體外研究
ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate.
ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs.
ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC
50
value against EC
80
concentrations of various GPR35 agonists in the region of 20 nM.