116308-56-6
中文名稱
116308-56-6
英文名稱
Watanipidine monohydrochloride
CAS
116308-56-6
分子式
C41H43ClN4O6
分子量
723.256
MOL 文件
116308-56-6.mol
116308-56-6 結構式
常見問題列表
生物活性
AE0047 Hydrochloride 是一種 calcium 阻滯劑，可用于高血壓癥的研究。靶點
Calcium Channel
體外研究
AE0047 Hydrochloride (4e) is a calcium antagonist. AE0047 inhibits [ 3 H]nimodipine binding to rat cardiac membrane homogenate with an IC 50 of 0.26 nM. AE0047 (1 μM) inhibits the high K + -evoked vascular smooth muscle contraction, and also inhibits [ 3 H]PN200-110 binding with a K i of 40.9 nM.
體內(nèi)研究
AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure with ED 30 of 1.1 mg/kg. AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine in aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP).