116229-36-8
116229-36-8 結(jié)構(gòu)式
基本信息
Bactenecin/Bactenecin, bovine
L-Arginine,L-arginyl-L-leucyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-valyl-L-valyl-L-isoleucyl-L-arginyl-L-valyl-L-cysteinyl-,cyclic (3®
L-Arginine, L-arginyl-L-leucyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-valyl-L-valyl-L-isoleucyl-L-arginyl-L-valyl-L-cysteinyl-, cyclic (3→11)-disulfide
(2R)-2-[[(4S,7R,10R,13R,16S,28S)-28-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-13,22-di(butan-2-yl)-10,25-bis[3-(diaminomethylideneamino)propyl]-6,9,12,15,18,21,24,27-octaoxo-7,16,19-tri(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
物理化學(xué)性質(zhì)
常見問題列表
?？咕氖且环N從牛嗜中性粒細(xì)胞中分離出來的有效的含12個氨基酸的環(huán)狀抗菌肽。它可抑制細(xì)菌和酵母菌(bacteria 和 yeast)的生長，并能殺死真菌紅毛癬菌(fungus Trichophyton rubrum)。它還可增加膜的通透性，抑制假蘋果芽孢桿菌(B. pseudomallei)的生長和生物膜的形成。
Bacteria; Yeast; Fungus
Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. Bactenecin inhibits the growth of
Escherichia coli
and
Staphylococcus aureus
at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus
Trichophyton rubrum
.
Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells.
Bactenecin exhibits stronger binding to LPS and induces perturbation of the inner membrane of live cells. Interaction of Bactenecin with model membranes results in changes in membrane fluidity and permeability, leading to leakage of dye across the membrane.