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1160927-48-9

中文名稱 IDE 1
英文名稱 IDE 1
CAS 1160927-48-9
分子式 C15H18N2O5
分子量 306.31
MOL 文件 1160927-48-9.mol
更新日期 2024/06/25 17:15:59
1160927-48-9 結(jié)構(gòu)式 1160927-48-9 結(jié)構(gòu)式

基本信息

中文別名
化合物IDE1
英文別名
IDE 1
IDE-1
IDE1
IDE-1
IDE1
IDE 1
2-{(e)-[(6-carboxyhexanoyl)hydrazono]methyl}benzoic Acid
1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Heptanedioic acid, 1-[2-[(2-carboxyphenyl)methylene]hydrazide]

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.63(Max Conc. mM)
DMSO:28.54(Max Conc. mg/mL);93.18(Max Conc. mM)
Ethanol:0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
形態(tài)白色固體。
顏色White to off-white

圖譜信息

IDE 1價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-100533IDE 1
IDE1
1160927-48-91mg500元
2024/11/08HY-100533IDE 1
IDE1
1160927-48-910 mM * 1 mLin DMSO640元
2024/11/08HY-100533IDE 1
IDE1
1160927-48-95mg950元

常見問題列表

生物活性
IDE1 是一種定形內(nèi)胚層誘導(dǎo)物,可能會(huì)被用于器官移植等方面。
體外研究

IDE1 enhances the definitive endoderm (DE) differentiation of human-induced pluripotent stem cells (hiPSCs) with Activin A/Wnt3a being significantly more potent in both 2D and 3D cultures compared to IDE1. IDE1 could efficiently induces DE differentiation through various protocols in vitro. Treatment of the hiPSCs-derived EBs with IDE-1 shows minor increase (p<0.01) of DE-markers cells compared to Activin A/Wnt3a treatment. IDE1 possess several advantages over other inducing factors including high permeability, influence, diversity, low cost, and easy to use and for the first time, Melton’s team showed that Activin A can be substituted by two cell-permeable small molecules, IDE1 and IDE2. IDE1 could induce phosphorylation of Smad2 after incubation for 24 h or more at levels comparable to those induced by Activin A treatment. Treatment of hiPSCs with IDE1 (2 mM) also leads to endodermal differentiation but with a significantly lower efficiency than Activin A/Wnt3a.

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