116-26-7
116-26-7 結構式
基本信息
番紅花醛
藏紅花醛
藏花醛/藏紅花醛
SAFRANAL (>
80%)
2,3-二氫-2,2,6-三甲基苯甲醛
2,3-二氫-2,2,6-三甲基苯甲醛(藏花醛,藏紅花醛)
FEMA 3389
SAFRANAL 88+%
Safranal (>80%)
SAFRANAL USP/EP/BP
SAFRANAL TECHN. ABOUT 95%
2,6,6-Trimethyl-1,3-cyclohexadienal
2,3-Dihydro-2,2,6-trimethylbenzalhyde
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE
1,1,3-TRIMETHYL-2-FORMYLCYCLOHEXA-2,4-DIENE
物理化學性質(zhì)
常見問題列表
藏紅花醛呈黃色液體狀，溶于乙醇等有機溶劑。
藏紅花醛可由藏紅花中的苦味素一苦藏花素在酸中水解取得，或由β-環(huán)檸檬醛或a-環(huán)香葉酸用氧化硒催化脫氫制得。
Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Western Blot Analysis
| Cell Line: | RAW264.7 cells and bone marrow-derived macrophages (BMDMs) |
| Concentration: | 10, 50 μM |
| Incubation Time: | For 1 h prior to lipopolysaccharide (LPS) stimulation (1 μg/ml) |
| Result: |
Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38. Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα. |
RT-PCR
| Cell Line: | RAW 264.7 cells |
| Concentration: | 10, 50 μM |
| Incubation Time: | For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h |
| Result: | Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. |
Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.
| Animal Model: | Female BALB/c mice (18-20 g) (DSS-induced colitis mice) |
| Dosage: | 200, 500 mg/kg |
| Administration: | PO; for 7 days |
| Result: | Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low. |