115150-59-9
中文名稱(chēng)
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
英文名稱(chēng)
(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11)
CAS
115150-59-9
分子式
C49H66N12O6S
分子量
951.19
MOL 文件
115150-59-9.mol
更新日期
2024/12/16 11:45:51
115150-59-9 結(jié)構(gòu)式
基本信息
中文別名
拮抗劑G TFA鹽化合物 T20481
拮抗劑G 三氟乙酸鹽
拮抗劑多肽ANTAGONIST G
P物質(zhì)肽[ARG6, DTRP7, 9, N-(NME)PHE8]- SUBSTANCE P(6-11)
英文別名
(arg6ANTAGONIST G
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2
(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11)
Substance P, fragment 6-11, [Arg6, D-Trp7,9, NMePhe8]
AntagonistG, Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2
[Arg6, D-Trp7,9, N-Me-Phe8]-SubstanceP fragment6-11
arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide
物理化學(xué)性質(zhì)
RTECS號(hào)PC4360070
儲(chǔ)存條件-15°C
形態(tài)固體
顏色Off-white to light yellow
水溶解性Soluble to 1mg/ml in water
常見(jiàn)問(wèn)題列表
生物活性
Antagonist G 是有效的后葉加壓素 (vasopressin) 的拮抗劑。Antagonist G 也是弱的 GRP 和緩激肽的弱拮抗劑。Antagonist G 可誘導(dǎo) AG-1 的轉(zhuǎn)錄，是癌細(xì)胞對(duì)化療增敏。體外研究
Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.
Antagonist G activates JNK1 in SCLC cells.
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.
Cell Viability Assay
| Cell Line: | SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells. |
| Concentration: | 0-100 μM. |
| Incubation Time: | 24 h. |
| Result: | Inhibited cell growh. |