1147823-21-9
中文名稱(chēng)
化合物 T34661
英文名稱(chēng)
SMDC818909
CAS
1147823-21-9
分子式
C14H13N5O
分子量
267.29
MOL 文件
1147823-21-9.mol
1147823-21-9 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
SMDC818909 is a potent and selective p97 inhibitor. The IC50 value of SMDC818909 decreased with increasing ATP concentration (26.0 ± 0.9, 11.5 ± 0.9, and 4.9 ± 0.9 μM at 5, 20, and 100 μM ATP, respectively), indicating that it behaved primarily uncompetitively with the ATP substrate. SMDC818909 represents a novel uncompetitive inhibitor with excellent physical and pharmaceutical properties that can be used as a starting point for drug discovery efforts.