1146963-51-0
中文名稱
N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE
英文名稱
J 147
CAS
1146963-51-0
分子式
C18H17F3N2O2
分子量
350.33
MOL 文件
1146963-51-0.mol
更新日期
2024/12/24 19:29:56
1146963-51-0 結(jié)構(gòu)式
基本信息
中文別名
2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亞甲基]酰肼 英文別名
J 147CS-1446
J147-API
J147/J-147
J-147?, >98%
Nootropic J147
J 147(Nootropic Powder)
N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE
(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide
2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)412.8±55.0 °C(Predicted)
密度1.18±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度DMSO:68.0(Max Conc. mg/mL);194.1(Max Conc. mM)
酸度系數(shù)(pKa)0.80±0.50(Predicted)
形態(tài)粉末
顏色Off-white to pink
InChIInChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3
InChIKeyHYMZAYGFKNNHDN-UHFFFAOYSA-N
SMILESC(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F
J-147價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 5mg | 500元 |
| 2024/11/08 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 10mg | 700元 |
常見問題列表
生物活性
J-147 是一種特別有效的，具有口服活性的神經(jīng)保護(hù)劑，可增強(qiáng)認(rèn)知能力。J-147 可透過血腦屏障 (BBB)。J-147 抑制單胺氧化酶 B (MAO B) 和多巴胺轉(zhuǎn)運(yùn)體 (dopamine transporter)，EC50 分別為 1.88 μM 和 0.649 μM。J-147 有潛力用于阿爾茨海默氏癥 (AD) 的研究。靶點(diǎn)
MAO B; Dopamine transporter
體外研究
J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC 50 value range of 0.06-0.115 μM) .
體內(nèi)研究
J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t
1/2
) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).
| Animal Model: | 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls |
| Dosage: | 200 ppm |
| Administration: | The diet was prepared by the addition of 200ppm; 6 months |
| Result: | While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147. |