1137359-47-7
中文名稱
BRD7552
英文名稱
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
CAS
1137359-47-7
分子式
C33H33N3O15
分子量
711.63
MOL 文件
1137359-47-7.mol
更新日期
2025/01/12 20:08:07
1137359-47-7 結(jié)構(gòu)式
基本信息
中文別名
4-(((((2R,3R,4S,5R,6S)-4,5-雙((苯并[D][1,3]二氧戊環(huán)-5-基氨基甲?；?氧基)-2-(羥甲基)-6-甲氧基四氫-2H-吡喃-3-基)氧基)羰基)氨基)苯甲酸乙酯 英文別名
CS-1560BRD7552
BRD7552 >=98% (HPLC)
BRD 7552
BRD-7552
BRD7552
Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside
α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate]
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)757.6±60.0 °C(Predicted)
密度1.53±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
酸度系數(shù)(pKa)11.81±0.20(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
BRD7552 是一種 PDX1 轉(zhuǎn)錄因子誘導(dǎo)劑，它上調(diào)了人類(lèi)原代胰島和導(dǎo)管細(xì)胞中 PDX1 的表達(dá)，并誘導(dǎo) PDX1 啟動(dòng)子的表觀遺傳變化與轉(zhuǎn)錄激活一致。BRD7552 增加胰島素表達(dá)。PDX1 是參與胰腺發(fā)育和β細(xì)胞功能的關(guān)鍵轉(zhuǎn)錄因子。體外研究
BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells.
BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner.
Western Blot Analysis
| Cell Line: | PANC-1 cells |
| Concentration: | 1.25, 2.5, 5 μM |
| Incubation Time: | 5 days |
| Result: | Induced a dose-dependent increase in PDX1 protein levels. |