天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>1125593-20-5

1125593-20-5

中文名稱 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
英文名稱 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
CAS 1125593-20-5
分子式 C28H33N5O4S
分子量 535.66
MOL 文件 1125593-20-5.mol
1125593-20-5 結(jié)構(gòu)式 1125593-20-5 結(jié)構(gòu)式

基本信息

中文別名
MPS1抑制劑(MPS1-IN-1)
1-[4-[[4-[[2-(異丙基磺?;?苯基]氨基]-1H-吡咯并[2,3-B]吡啶-6-基]氨基]-3-甲氧基苯基]哌啶-4-醇
英文別名
Mps1-IN-1
Mps1 inhibitor
Mps1 inhibitor 1
1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
1MPS1-IN-1
1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
4-Piperidinol, 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-

物理化學(xué)性質(zhì)

密度1.354±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度insoluble in H2O; ≥16.05 mg/mL in DMSO; ≥9.26 mg/mL in EtOH
酸度系數(shù)(pKa)14.76±0.20(Predicted)
形態(tài)固體
顏色Light yellow to yellow

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335

常見問題列表

生物活性
Mps1-IN-1 是一種有效的,選擇性的,ATP 競爭性的 Mps1 抑制劑,IC50 和 Kd 值分別為 367 nM 和 27 nM。
靶點

Mps1

367 nM (IC 50 )

Mps1

27 nM (Kd)

ALK

21 nM (Kd)

LTK

29 nM (Kd)

PYK2

280 nM (Kd)

FAK

440 nM (Kd)

IGF1R

750 nM (Kd)

INSR

470 nM (Kd)

CLK1

1900 nM (Kd)

ERK2

2900 nM (Kd)

INSRR

1200 nM (Kd)

TNK1

2600 nM (Kd)

TNK2

3100 nM (Kd)

GAK

1100 nM (Kd)

體外研究

Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 367 nM and 27 nM. Mps1-IN-1 also has high affinity for ALK, and LTK, with K d s of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 (10 μM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 (5-10 μM) suppresses the proliferative capacity of HCT116.

"1125593-20-5" 相關(guān)產(chǎn)品信息