112208-00-1
中文名稱(chēng)
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
英文名稱(chēng)
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
CAS
112208-00-1
分子式
C81H156N10O13S
分子量
1510.23
MOL 文件
112208-00-1.mol
更新日期
2024/12/16 11:45:49
112208-00-1 結(jié)構(gòu)式
基本信息
中文別名
PAM?CYS-SER-(LYS)?,鹽酸鹽S-[2,3-二[(1-氧代十六烷基)氧基]丙基]-N-(1-氧代十六烷基)-L-半胱氨酰基-L-絲氨?；?L-賴(lài)氨酰基-L-賴(lài)氨?；?L-賴(lài)氨?；?L-賴(lài)氨酸
(2S)-6-AMINO-2-[[(2S)-6-AMINO-2-[[(2S)-6-AMINO-2-[[(2S)-6-AMINO-2-[[(2S)-2-[[(2R)-3-[2,3-DI(HEXADECANOYLOXY)PROPYLSULFANYL]-2-(HEXADECANOYLAMINO)PROPANOYL]AMINO]-3-HYDROXYPROPANOYL]AMINO]HEXANOYL]AMINO]HEXANOYL]AMINO]HEXANOYL]AMINO]HEXANOIC ACID
英文別名
sineP 3C
Pam3CSK4
Pam3CSK41
Pam3CysSK4
Pam3Cys-SKKKK
Pam3Cys-Ser-(Lys)4
PaM3Cys-Ser-(Lys)4 . 3HCl
PAM3-CYS-SER-LYS-LYS-LYS-LYS-OH
PamCys-Ser-(Lys), Hydrochloride
物理化學(xué)性質(zhì)
沸點(diǎn)1408.0±65.0 °C(Predicted)
密度1.054±0.06 g/cm3(Predicted)
儲(chǔ)存條件-15°C
溶解度Soluble to 1 mg/ml in 50% Ethanol / H2O
酸度系數(shù)(pKa)3.27±0.10(Predicted)
形態(tài)凍干固體
常見(jiàn)問(wèn)題列表
用途
本品主要用于實(shí)驗(yàn)室有機(jī)合成中和化工醫(yī)藥研發(fā)過(guò)程中。生物活性
Pam3CSK4 是一種 Toll 樣受體 1/2 (TLR1/2) 激動(dòng)劑，對(duì)人 TLR1/2 的 EC50 為 0.47 ng/mL。體外研究
Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides.
Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant
Staphylococcus aureus
.
體內(nèi)研究
Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice.
| Animal Model: | Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2 tm1Kir /J (TLR2 -deficient) mice |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneally (i.p.); once a day for 9 days |
| Result: | After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12. |