1116745-06-2
中文名稱
DUOCARMYCIN
英文名稱
DuocarMycin
CAS
1116745-06-2
分子式
C26H26ClN3O3
分子量
463.96
MOL 文件
1116745-06-2.mol
更新日期
2024/10/09 11:06:39
1116745-06-2 結構式
物理化學性質
沸點712.9±60.0 °C(Predicted)
密度1.345±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.47±0.40(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Duocarmycin DM free base 是一種 DNA 小溝烷基化劑 (DNA minor-groove alkylator)，是一種抗體藥物結合物 (ADCs) 毒素。Duocarmycin DM free base 因特有的結構而具有抗癌活性。靶點
|
Daunorubicins/Doxorubicins
|
體外研究
The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from
Streptomyces sp.
that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture.
Duocarmycin shows cytotoxicity to several human cancer cells, with IC
50
of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively.