110417-88-4
中文名稱
DOLASTATIN 10
英文名稱
dolastatin 10
CAS
110417-88-4
分子式
C42H68N6O6S
分子量
785.09
MOL 文件
110417-88-4.mol
更新日期
2024/12/23 17:39:05
110417-88-4 結(jié)構(gòu)式
基本信息
中文別名
尾海兔素10尾海兔素10, >99%
微管蛋白聚合抑制劑(DOLASTATIN 10)
英文別名
DLS 10CS-1367
Nsc376128
Dolastain10
B720389K560
dolastatin 10
Dolastatin 10 (NSC-376128)
From dolabella auricularia (sea hare)
Dolastatin 10,DLS 10,NSC 376128, >99%
6-[bis[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl] amino]-6-oxohexanoic acid
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點903.6±65.0 °C(Predicted)
密度1.116±0.06 g/cm3(Predicted)
儲存條件Store at -20°C,unstable in solution, ready to use.
溶解度≥78.5 mg/mL in EtOH; insoluble in H2O; ≥67.2 mg/mL in DMSO
酸度系數(shù)(pKa)13.81±0.46(Predicted)
形態(tài)粉末
顏色White to off-white
常見問題列表
生物活性
Dolastatin 10 (DLS 10) 是一種有效的從海洋軟體動物Dolabela auricularia中分離出來的抗有絲分裂肽，抑制微管蛋白聚合。靶點
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Auristatin
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體外研究
Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI 50 values of 10 ?5 -10 ?6 μg/mL (10 ?2 -10 ?3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.