108477-18-5
中文名稱
108477-18-5
英文名稱
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
CAS
108477-18-5
分子式
C19H14N2O7S
分子量
414.39
MOL 文件
108477-18-5.mol
108477-18-5 結(jié)構(gòu)式
基本信息
中文別名
半胱天冬酶和細(xì)胞凋亡激活劑(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5) 英文別名
NSC-144303Ubiquitin Isopeptidase-IN-G5
Ubiquitin Isopeptidase Inhibitor I
G5, Ubiquitin Isopeptidase Inhibitor I
Ubiquitin Isopeptidase Inhibitor I, G5
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303)
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
物理化學(xué)性質(zhì)
熔點(diǎn)233.5-234.5 °C
沸點(diǎn)693.0±55.0 °C(Predicted)
密度1.541±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C,unstable in solution, ready to use.
溶解度≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
108477-18-5價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 5mg | 770元 |
| 2024/11/08 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 10mg | 1330元 |
| 2024/11/08 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 25mg | 2660元 |
常見問題列表
生物活性
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依賴的半胱天冬酶和細(xì)胞凋亡的激活劑，對(duì)E1A和E1A/C9DN細(xì)胞的IC50值分別為1.76和1.6 μM。靶點(diǎn)
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)
體外研究
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC 50 s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.