107534-93-0
107534-93-0 結(jié)構(gòu)式
基本信息
安五酯素
安五脂素對照品
安五脂素標(biāo)準(zhǔn)品
安五脂素, >98%
安五脂素 (安五酯素)
安五脂素, 來源于五味子
ANWULIGAN 安五酯素
Anwuligan
Macelignan
ANWULIGNAN
(+)-Anwulignan
Macelignan, >98%
Anwuligan（Macelignan）
Macelignan >=98% (HPLC)
Anwuligan, 98%, from Schisandra chinensis
4-(2S,3R)-4-(1,3-benzodioxol-5-yl-2-3-dimetybty]-2_methoxyphenol
物理化學(xué)性質(zhì)
常見問題列表
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COX-2
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Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm 2 , reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells.
Cell Viability Assay
| Cell Line: | Hacat cells |
| Concentration: | 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM |
| Incubation Time: | 72 hours |
| Result: | Induced cell death by UVB irradiation at 30 mJ/cm 2 from 10 μM. |
Western Blot Analysis
| Cell Line: | Hacat cells |
| Concentration: | 0.1 μM; 0.5 μM;1 μM |
| Incubation Time: | 24 hours |
| Result: | Reduced UVB-induced COX-2 expression in cells. |
Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ- db/db mice.
| Animal Model: | Male C57BL/KsJ- db/db mice |
| Dosage: | 15 mg/kg |
| Administration: | Oral administration; 15 mg/kg; every day for three weeks |
| Result: | Significantly reduced the blood glucose levels in mice. |